Bronchogen is a tetrapeptide made up of four amino acids in sequence: Alanine-Glutamic acid-Aspartic acid-Leucine (Ala-Glu-Asp-Leu). It is a bioregulatory peptide primarily recognized for its role as a DNA-stabilizing agent and its potential bronchodilating and anti-inflammatory properties in respiratory conditions.
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Bronchogen is a DNA-stabilizing tetrapeptide composed of four amino acids (Ala-Glu-Asp-Leu) that acts as a bioregulator specifically targeting lung tissue. The peptide’s primary effects include reducing inflammation in lung tissue, improving epithelial cell function, and increasing surfactant production.
| Property | Value |
|---|---|
| Peptide Sequence | Ala-Glu-Asp-Leu |
| Molecular Formula | C18H30N4O9 |
| Molecular Weight | 446.45 g/mol |
| Synonyms | Peptide AEDL |
Bronchogen is a tetrapeptide composed of four amino acids (Ala-Glu-Asp-Leu) that has been studied for its potential bioregulatory effects, particularly in lung tissue. This DNA-stabilizing peptide has shown promise in stimulating cell renewal processes and enhancing the functional activity of bronchial epithelial cells. Research suggests that Bronchogen may interact with specific DNA sequences, particularly those containing CTG motifs, potentially influencing gene expression and epigenetic regulation.
The peptide’s mechanisms of action are thought to involve modulating signal transduction pathways and transcription factors at the DNA level. Research areas for Bronchogen include its application in treating lung conditions, its role as a plant growth factor, and its potential as an anti-aging geroprotective agent.
Bronchogen has been demonstrated to stabilize DNA by increasing the melting temperature of DNA from calf thymus and mouse liver by 3.1°C within a specific molar ratio range (0.01-0.055). This suggests that bronchogen acts as a DNA-stabilizing agent, although further increases in concentration do not enhance this effect. The peptide does not show specificity for adenine-thymine or guanine-cytosine base pairs, indicating a strong but non-specific binding to DNA, primarily interacting with nitrogen bases on both strands.1
Bronchogen, along with other short peptides, can penetrate animal cells and interact with nuclear components, including DNA. It shows preferential binding to deoxyribooligonucleotides containing CTG sequences, which are significant for cytosine DNA methylation in eukaryotes. The peptide’s ability to bind specific DNA sequences suggests a potential role in epigenetic regulation, possibly influencing gene activity and cellular functions from early developmental stages.2
Bronchogen, also known as ADEL, has been shown to regulate the expression of genes involved in bronchial epithelium differentiation and maintenance. It influences the expression of genes such as NKX2-1, SCGB1A1, and FOXA1, which are crucial for bronchial epithelial cell function. The peptide affects the levels of proteins like Ki67 and Mcl-1, which are associated with cell proliferation and survival, indicating its role in promoting bronchial epithelial cell proliferation and potentially protecting against pulmonary pathologies. Additionally, it may have a geroprotective effect, potentially contributing to the preservation of lung function with aging. 3
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Bronchogen (20mg)Availability: In stock
