Cortagen Peptide Description
Cortagen (Ala-Glu-Asp-Pro) is a tetrapeptide member of the Khavinson peptide bioregulator family, a group of short peptides typically consisting of 2-4 amino acids. These peptides are known for their powerful bioregulatory effects and their ability to influence gene expression in tissue-specific ways. Cortagen shows significant neuronoprotective and regenerative properties, particularly in the context of nerve injury, and it may also have implications for cardiovascular health.
Peptide Information
| Property |
Value |
| Peptide Sequence |
Ala-Glu-Asp-Pro |
| Molecular Formula |
C17H26N4O9 |
| Molecular Weight |
430.17 g/mol |
| CAS Number |
335591-03-2 |
| PubChem CID |
18439621 |
| Synonyms |
SCHEMBL5491754 |
Cortagen Structure
Source: PepDraw
Cortagen Research
Cortagen exhibits promising neuronoprotective and nerve regeneration properties, with potential applications in neurotrophic therapies. Its ability to modulate gene expression in the heart also suggests broader therapeutic implications, particularly in cardiovascular health. However, its effects on immunity and hemostasis appear limited compared to similar peptides. Further research is needed to fully understand the mechanisms and potential clinical applications of cortagen.
Neuronoprotective Effects
Cortagen has been shown to exhibit neuronoprotective properties. Studies have demonstrated that cortagen can modulate neuronal activity by affecting the resting potential and action potential of neurons. Specifically, cortagen hyperpolarizes neurons and reduces their spontaneous activity, indicating its activating and neuronoprotective action.1
Role in Nerve Regeneration
Cortagen has been investigated for its role in nerve regeneration, particularly in the context of peripheral nerve injuries. Research involving rat models has shown that cortagen can stimulate the growth of nerve fibers during the initial stages of regeneration. However, its effects on the conductivity of regenerating nerve fibers were not significant, as measured by compound action potentials. The peptide did not notably affect the conduction velocity of action potentials through the suture site of injured nerves, suggesting that its primary benefits may lie in the early stages of nerve repair.2
Gene Expression and Cardiovascular Effects
Cortagen has also been studied for its impact on gene expression, particularly in the heart. Microarray analyses have revealed that cortagen can significantly alter the expression of numerous genes in the heart, which may contribute to its therapeutic effects. These changes in gene expression suggest potential benefits in cardiovascular and cerebrovascular health, although the specific mechanisms remain to be fully elucidated.3
Immunity and Hemostasis
In studies involving hypophysectomized chickens and older birds, cortagen did not significantly affect parameters related to erythrocytes, immunity, and hemostasis. This contrasts with another tetrapeptide, epithalon, which was effective in eliminating shifts in these parameters. The difference in terminal amino acids between cortagen and epithalon may account for their differing effects on these physiological systems.4
References
- Shabanov, P., & Vislobokov, A. (2013). Neuronoprotective action of cortexin andcortagen. Reviews on Clinical Pharmacology and Drug Therapy, 11, 17-25. https://doi.org/10.17816/RCF11217-25.
- Kolosova, L., Moiseeva, A., Turchaninova, L., Malinin, V., Polyakov, E., Nozdrachev, A., & Khavinson, V. (2002). The Delayed Effect of Cortagen on the Restoration of Injured Nerve Function. Doklady Biological Sciences, 384, 183-184. https://doi.org/10.1023/A:1016098302564.
- Anisimov, S., Khavinson, V., & Anisimov, V. (2004). Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.. Neuro endocrinology letters, 25 1-2, 87-93 . https://pubmed.ncbi.nlm.nih.gov/15159690/
- Kuznik, B., Pateiuk, A., Baranchugova, L., & Rusaeva, N. (2008). [Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds]. Advances in gerontology = Uspekhi gerontologii, 21 3, 372-81. https://pubmed.ncbi.nlm.nih.gov/19432169/
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Endotoxin Cortagen
Cortagen (251526)
Cortagen (251526E)
Endotoxin Cortagen
Cortagen(10177)
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