N-Acetyl Selank Amidate Product Description
Selank is a heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with significant anxiolytic, cognitive-enhancing, and immunomodulatory effects. Its ability to modulate the GABAergic system and influence gene expression underlies its therapeutic research potential, particularly in managing anxiety and stress-related conditions.
N-Acetyl Selank is a modified version of Selank designed to improve its pharmacological properties. The addition of an acetyl group at the N-terminus enhances its stability, potency, and ability to cross the blood-brain barrier.
Peptide Information
| Property |
Value |
| Peptide Sequence |
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2 |
| Molecular Formula |
C33H57N11O9 |
| Molecular Weight |
751.9 g/mol |
| CAS Number |
129954-34-3 |
| PubChem CID |
11765600 |
| Synonyms |
Selank, 129954-34-3, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro, TP-7 |
N-Acetyl Selank Peptide Structure
Source PubChem
N-Acetyl Selank Research
Selank is a multifaceted peptide with significant potential in treating anxiety, cognitive impairments, and stress-related physiological changes. Its ability to modulate the GABAergic system, enhance cognitive function, and exert immunomodulatory effects positions it as a versatile therapeutic agent.
Anxiolytic and Cognitive Effects
Selank has demonstrated significant anxiolytic properties, comparable to classical benzodiazepines, without the associated side effects such as dependence and memory impairment1. It has been shown to reduce anxiety in conditions of chronic stress and improve cognitive functions, such as memory and attention, particularly in the context of ethanol-induced impairments. The peptide’s ability to regulate brain-derived neurotrophic factor (BDNF) content in the hippocampus and prefrontal cortex is thought to contribute to its cognitive-enhancing effects2.
Immunomodulatory and Antiviral Properties
Beyond its neurological effects, Selank also exhibits immunomodulatory and antiviral properties. It can significantly alter the expression of genes related to chemokines, cytokines, and their receptors, suggesting a role in immune response modulation3. These properties make Selank a promising candidate for therapeutic applications beyond anxiety and cognitive disorders.
Stress Mitigation and Physiological Effects
Selank has been shown to mitigate stress-induced physiological changes. In animal models, it reduces stress-related morphological changes in organs such as the liver and colon, indicating its potential to alleviate stress-induced damage. These effects are likely due to its multifunctional biological activity, which includes reducing corticosterone levels and promoting adaptation to stress4.
References
- Vyunova, T., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.. Protein and peptide letters, 25 10, 914-923 . https://doi.org/10.2174/0929866525666180925144642.
- Kolik, L., Nadorova, A., Antipova, T., Kruglov, S., Kudrin, V., & Durnev, A. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of Experimental Biology and Medicine, 167, 641 – 644. https://doi.org/10.1007/s10517-019-04588-9.
- Kolomin, T., Mikhalskaia, P., & Sedelnikova, A. (2023). Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments. Journal of Clinical Physiology and Pathology. https://doi.org/10.59315/jiscpp.2023-2-2.16-18.
- Mukhina, A., Mishina, E., Bobyntsev, I., Medvedeva, O., Svishcheva, M., Kalutskiĭ, P., Andreeva, L., & Myasoedov, N. (2020). Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank. Bulletin of Experimental Biology and Medicine, 169, 281 – 285. https://doi.org/10.1007/s10517-020-04868-9.
Certificate of Analysis (COA) for Every Batch
A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity, and batch quality through independent laboratory testing. Every compound from BioLongevity Labs ships with a COA tied to its specific batch, so researchers can confirm exactly what they received before it enters a protocol.
Each COA reports results from third-party laboratory analysis, including:
- Ultra-high-performance liquid chromatography with mass spectrometry (UHPLC-MS) for purity, typically confirmed at 99% or higher
- Mass identification for molecular confirmation and content quantitation
- Endotoxin quantitation by Limulus amebocyte lysate (LAL) assay where applicable
- Visual and physical characterization of the finished material
How to verify a COA independently
Every certificate can be checked against the issuing laboratory’s own records, not just the copy hosted here. Verification does not depend on BioLongevity Labs.
- MDx BioAnalytical Laboratory certificates carry a QC tracking number and a search code. Newer certificates also carry a QR code. Scan the code, or enter the search code at mdxbiolabs.com, to pull the official record.
- BioRegen reports of analysis carry a Report ID and a Validation Key. Scan the QR code on the certificate to open the official record, or reference both identifiers when contacting the laboratory at the address printed on the report.
- SafeCert Labs certificates, which appear on a number of earlier batches, carry a COA number and the signature of the reporting chemist. Reference that number when requesting confirmation from the laboratory directly.
Batches are frequently tested by both laboratories independently. When two certificates exist for the same lot, each one resolves at its own issuing laboratory, which lets a researcher confirm the same material twice through two unrelated sources.
COAs are sourced from independent certified labs rather than in-house testing alone, giving researchers a verifiable record of molecular integrity for each batch. All compounds are supplied for research use only.
Review the COAs for this batch below, or browse the full COA library.
N-Acetyl-Selank Amidate (11233)
N-ACETYL SELANK AMIDATE (251444)
NA_Selank(10743)
Endotoxin N-AcetylSelankAmidate
NASA(10183)
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